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Archives
this is just weird.
hey sam, the presents go UNDERNEATH the tree.
it’s about time i started to put some excerpts from the neuroethics book edited by judy illes. here’s another wonderful ditty from chapter 11: a picture is worth 1000 words, but which 1000?
italics are mine.
…from ch. 11 in Neuroethics…
What constitutes a ‘significantly greater’ activation than another, is in a way, in the eye of the beholder… lowering the threshold will create more regions that are statistically significant, whereas raising the threshold will reduce the number of significant regions. The choice of the threshold is largely determined by convention among researchers, rather than absolute standards. Reporting brain activation patterns is therefore primarily a statistical interpretation of a very complex dataset, and may be interpreted differently by different researchers. (Canli and Amin 2002)
YES!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
While group averages are vital for achieving acceptable signal-to-noise ratios, individual differences, from both anatomical and functional variability may become diluted and overshadowed (Beaulieu 2001; President’s Council on Bioethics 2004). When dealing with single-subject data, as is the case for presurgical planning, it is often desirable to minimize false-negative voxels in order to avoid erroneously excising potentially healthy tissue (M. P. Kirschen et al., under review). Outside the clinical setting, we can easily extend these considerations to any analytic objective set to pinpoint activation areas for function in individuals:
…the image of an activation pattern from a poorly designed study is visually indistinguishable from one based on an exemplary study. It takes a skilled practitioner to appreciate the difference. Therefore, one great danger lies in the abuse of neuroimaging data for presentations to untrained audiences such as courtroom juries. What can be easily forgotten when looking at these images is that they represent statistical inferences, rather than absolute truths. (Canli and Amin 2002)
YES!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Lastly, the interpretability of fMRI activation maps is dependent on how the data are displayed. The colour-coded statistical maps are usually overlaid on high-resolution anatomical MR images to highlight the brain anatomy. There are several media for displaying these composite images. The most rigorous is to overlay the functional data onto single anatomical slices in any imaging plane. While this is the most comprehensive means of examining the data, it is often difficult to localize the activations to a particular region, given a particular scan plane, and researchers are limited in the number of slices they can include in a publication or lecture. Alternatively, the activation maps can be presented on a three-dimensional rendered brain. While this technique gives good visualization of prominent external brain structures, internal regions like the hippocampus or basal ganglia are not well characterized on these models. Researchers often use both of these techniques to examine data, but ultimately choose the one that best highlights the main results of the study for presentation.
Since basic research is usually done to infer characteristics bearing on populations, the extension to individual applications is challenged by a scarcity of normative data that can support, for example, conclusions of abnormal activation (Rosen and Gur 2002). There are risks that measures will vary between individuals or that the meaning of data compared with normal individuals will be difficult to establish. Abnormality and predictive validity could even be more problematic in the context of real-world behaviours, especially those that are potentially value laden or culturally determined (Illes et al., 2003).
In my post-synapse, pre-Christmas, bored at work phase I really cannot find it in me to blog very critically these days. Something more serious will come up soon, but, quite frankly, I love Daily Dose of Imagery now more than ever and would rather hang around his beautiful images.
if you haven’t seen PhD Comics, now’s the time.
is a neuroscience carnival devoted to all areas of neuroscience, including neurobiology, psychology, psychiatry, and neural systems — healthy brains to perverse minds — neurotransmitters to theories of mind.
To kick off the final installment of The Synapse before the new year, Corpus Callosum gets a little Popperian on the falsification of hypotheses and the connection between antidepressants and suicide. In the same vein, the Neurocritic bites into an antidepressant study and outlines why some of the claims being made are hard to swallow.
Bearing in mind Corpus Callosum’s reiteration that ‘correlation does not imply causation’, we turn to Vaughan’s submission of an fMRI study related to psychopathy at Mind Hacks. Non Causa Pro Causa has interesting implications for the old nature/nurture debate and makes neuroimaging studies all the more nuanced. For more on psychopathy, I’d recommend Inside the Mind of a Psychopath on CBC’s Quirks & Quarks.
On Autism, Dr. Deborah Serani, host of the previous Synapse, highlights a paper on genetic mutation and its link to the risk of Autism.
Musings on Neurology and Lenitives In Simplistic Art outlines his top 5 strategic areas for research in neuroscience. Is the NIH accepting grant proposals in blog format? While quite broad in scope, there are some sympathies on this end to neuroinformatics and making conversion between file formats easier or potentially adopting a more standard format (imaging people, I know you sympathize. Oh, to be back in the DICOM days). Hat tip on Neuroethics, look north.
On touching brains in a bad way, the Neurophilosopher elaborates on every neuroscientist’s perennial favourite: Phineas Gage. A lot seems to fall out of rod-shaped objects piercing one’s head, although tamping irons may not be that common these days. What, you ask, might be? Chopsticks of course!

Could a young man like this (and his chopsticks) be a key contributor to stem cell research? Shelley at Retrospectacle says yes!
On touching brains in a good way, Jake at Pure Pedantry looks at brain stimulation and the therapeutic value of brain stimulation for Parkinsonism. For coverage of Deep Brain Stimulation (DBS), including a talk by a Parkinson’s patient, check out the Dana Centre’s webcast on DBS during the 2006 Brain Awareness Week at the Science Museum in London.
Transcranial direct current stimuliation (tDCS) is another good touch, albeit less invasive. The Fibromyalgia Research Blog reviews a paper on tDCS as a treatment for fibromyalgia pain.
For a more magnetic touch, consider the Neurocritic’s post on repetative transcranial magnetic stimulation, or rTMS.
Alvaro at SharpBrains interviews Dr. Elkhonon Goldberg on brain fitness and cognitive training and looks at what successful traders and students have in common. I concur on the point of bloated textbooks here in North America. That said, if you’d really like to know what Penfield or Newton thought, read them! Don’t just read a synopsis in a textbook! It’s unfortunate that there are not more programs like St. John’s Great Books program out there.
Outside of print, I Am A Scientist! caught up with Dr. Mary Harrington from Smith College at the Society for Neuroscience (SfN) conference in Atlanta this past October. Listen to a discussion on the Faculty for Undergraduate Neuroscience live online, Sunday, December 10th at Noon (GMT -0600) on CKUW 95.9 FM. Unable to listen? The show will be archived on the show website. In the meantime, lend your ears to another discussion at SfN, this time with Dr. Gladys Maestre from the University of Zulia in Maracaibo, Venezuela on neuroscience and developing countries. Part 1 / Part 2 (MP3).
And heck, I’ll be hosting The Motel 6 later this morning (sigh, it’s late) live on CKUW 95.9 FM and ckuw.ca starting at 10AM (GMT -0600) on Sunday. Tune in!
Should you listen to the interview with Dr. Harrington, circadian rhythms will likely be on your mind. A Blog Around The Clock points to the refinement of questions in circadian rhythm research.
And, speaking of the molecular level, PZ Myers gives a near textbook explanation of the notch receptor.
While Sandy at The Mouse Trap makes his conjectures on the evolutionary trajectory of colour vision, Pete at Brain Hammer brings us back to philosophy and reminds us that a scientific theory, necessarily being falsifiable, is only as good as the predictive power it holds.
And it looks like that’s a wrap folks. Thanks for stopping by, see you in the new year, and in the words of the infamous Ivan Hrvatska, See you at party!
UPDATE
Synapse and Encephalon are consolidating! Regular and potential contributors to The Synapse are encouraged to submit posts here or by emailing encephalon.host at gmail.com. The next Encephalon will be held at Neurotopia on December 18th.
any recommendations for a good documentary or film on anorexia?
has anyone seen ‘catherine’?

